Stepwise Design of a High Signal-to-Background Ratio Dual-Emission Probe for Imaging Mitochondrial HClO and Microenvironmental Changes in Diabetic Liver and Kidney Injury.
Diabetic hepatorenal injury is linked to oxidative stress, mitochondrial dysfunction, and ferroptosis. Elevated hypochlorous acid (HClO) levels, together with alterations in mitochondrial polarity and viscosity, are key indicators of diabetic hepatorenal injury. Early, in situ, real-time monitoring of these signals is...