USP11 exacerbates intestinal I/R injury by driving NCOA4-mediated ferritinophagy and ferroptosis via Beclin-1 deubiquitination.
Intestinal ischemia/reperfusion (I/R) injury is a life-threatening clinical condition associated with high mortality and limited therapeutic options. Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has emerged as a critical contributor to intestinal I/R injury. Nuclea...