Hydrogel Delivery of Demineralized Bone Matrix Augmented with ROS-Triggered Biomineralization and Trb3 Activation for Enhanced Bone Regeneration
Cranial bone defects remain a significant clinical challenge due to limited intrinsic regenerative capacity and an adverse oxidative microenvironment that impairs osteogenesis. Demineralized bone matrix (DBM), a clinically used bone graft substitute, exhibits osteoinductive potential but suffers from inconsistent perfo...