Open access
Aug 2026
Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs.
X-ray crystal structures of ELAV RNA recognition motif 3 (RRM3) are determined to reveal that multimerization is mediated by two evolutionarily conserved interfaces in non-RNA-binding parts of the RRM to form a tetramer and RNA binding is not required for multimerization.
Thomas C. Dix, David W. J. Mcquarrie, Ulrike Bräuer et al.
· Genes & Development · 0 citations