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Jul 2026

Naringenin from Citrus aurantium L. alleviates loperamide-induced constipation by inhibiting excessive autophagy-mediated apoptosis in interstitial cells of Cajal via the AKT1 signaling pathway.

Constipation is a prevalent gastrointestinal disorder frequently associated with the dysfunction and loss of Interstitial Cells of Cajal (ICCs). Zhishi, the dried young fruit of Citrus aurantium L. (CAL), is a traditional medicine used for constipation; however, its specific bioactive constituents and mechanisms of act...

Ren-Jing Lin, Ying Nie, Yongheng He et al. · 0 citations

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