Impact of single-use bioreactor bag materials on Spodoptera frugiperda cell expansion for recombinant adeno-associated virus manufacturing.
Recombinant adeno-associated virus production for gene therapy applications commonly relies on the Spodoptera frugiperda 9 (Sf9) baculovirus infection platform. The process encompasses cell expansion from flasks through intermediate-scale bioreactors to large-scale production. A critical challenge in this process is su...