Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis
Cartilage-targeted HPcLW nanoparticles are fabricated via electrostatic self-assembly of human serum albumin and poly-L-lysine with collagen II-binding peptide, co-loaded with lycopene and WTAP siRNA to counteracts the senescence loop, establishing the WTAP/PAI-1 axis as a therapeutic target and highlighting co-deliver...