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Min-Zhang Li

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#artificial intelligence Preprint Sep 2026

ProtLingo: Efficient Protein Language Modeling via Conditional Memory and Expert Routing

Proteins perform diverse cellular functions, and even single amino-acid substitutions can alter stability, activity, or molecular interactions. Protein language models (PLMs) provide a scalable approach for modeling such sequence--function relationships from unlabeled sequences, but increasing the size of dense Transfo...

Ming-Rui Li, Si-Xian Shen, Min-Zhang Li et al. · 0 citations
Jul 2026

Evolution-Aware MSA Reasoning for Subsampling via Factor Graphs

Experiments show that AP-REASONER outperforms baseline subsamplers on structure-sensitive downstream tasks and enables controllable recovery of alternative protein conformations, highlighting the value of modeling MSA subsampling as a controllable optimization problem, where factor-graph reasoning offers an effective a...

Zhangzhi Xiong, Min-Zhang Li, Hao Yu et al. · 0 citations

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