Age-related loss of miR-378d promotes cardiomyocyte senescence via the SH3GL2/Calpain-1/ROS signaling axis.
Cardiac aging is the major risk factor and important pathogenic foundation for cardiovascular diseases (CVDs) in the elderly. Various miRNAs have been reported to participate in this process. However, the precise mechanisms through which distinct miRNAs contribute to cardiac aging remain to be fully elucidated. In this...