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Min-Zhi Xu

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Oct 2026

Drug-drug interaction between vonoprazan and imatinib: in vivo pharmacokinetics and in vitro metabolic inhibition characterization.

1. Vonoprazan and imatinib may be co-prescribed in patients with acid-related disorders, but the pharmacokinetic consequences of this combination remain unclear.2. We evaluated the effects of vonoprazan on imatinib pharmacokinetics in rats and compared metabolic inhibition in human and rat liver microsomes.3. Rats (n =...

Fei Dai, Yu Wang, Pei-Wu Geng et al. · 0 citations

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