Ming-Chao Liu

Electrostatic–Hydrophobic Competition Induces Re-Entrant Phase Separation in Designer Polypeptides

The liquid–liquid phase separation (LLPS) of intrinsically disordered proteins is governed by a delicate balance among electrostatic, hydrophobic, and aromatic interactions, yet how residue identity reshapes this balance remains incompletely understood. Although significant progress has been made toward establishing a...