Review
Open access
Sep 2026
From reference-genome prediction to causal generalization: sequence-to-function models for plant regulatory genomics
This Mini Review summarizes seq2func modelling in plant regulatory genomics, discusses plant-specific challenges and the complementary value of observational and perturbation assays, and proposes evaluation frameworks based on biologically meaningful distribution shifts.
Ming-Fang Zhan, Rui-Gang Wu
· Frontiers in Plant Science · 0 citations