Ming-Guo Zhou

Novel Piperidine Amide Derivatives Containing a Tetrazole Moiety: Safe Synthesis Methods, Molecular Design, Antioomycete Evaluation, and Action Mechanism

The novel piperidine amide derivatives containing a tetrazole moiety were first constructed using a safer synthetic method in which sodium azide was substituted with diphenyl azidophosphate (DPPA). Compound D16 (EC50 = 0.0025 μg/mL), which was screened using an in vitro test against oomycetes, exhibited excellent inh...