Ming-Hao Yang

Palladium-Catalyzed Tandem Dearomative Heck Reaction of N-Propiolyl Indoles or Pyrroles with Aryl Bromides.

An efficient Pd-catalyzed tandem dearomative Heck reaction of N-propiolylindoles or pyrroles with aryl bromides has been developed. The protocol provides access to a series of benzopyrrolizinone and pyrrolizinone derivatives bearing a quaternary stereocenter and a tetrasubstituted olefin moiety in moderate to high yiel...