Author

Ming-Jiang Xu

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Open access Aug 2026

Site-specific N6-methyladenosine fine tunes CTCF/cohesin-defined enhancer-promoter interactions and oncogenic transcription program

Abstract N6-methyladenosine (m6A) of RNAs plays an important role in RNA stability and gene expression. However, it remains unknown how site-specific m6A on individual RNA is decoded to regulate chromatin architecture and transcriptional reprogramming. Here, we show that m6A modification of HOTTIP lncRNA is highly enri...

Su-Ming Huang, Hua-Cheng Luo, Karina Hamamoto et al. · Research Square · 0 citations

Open access Sep 2026

Integrator governs NF-κB dwell time on chromatin to drive inflammatory transcription

NF-κB must remain bound to chromatin long enough to activate innate immune genes, but what stabilizes this transcriptionally productive state is unknown. Here, we identify the Integrator complex as an essential determinant of NF-κB chromatin residence in mouse and human cells. Integrator associated with NF-κB and co-oc...

P. Cingaram, Jing-Yin Yue, Fan Liu et al. · bioRxiv · 0 citations