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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Mingliang Wang

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Oct 2026

STING hinders XIAP-mediated degradation of NLRP3 to lock the inflammasome in a hyperactivated state during pulmonary ischemia-reperfusion injury.

Pulmonary ischemia-reperfusion (I/R) injury activates the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome to drive sterile inflammation. Although stimulator of interferon genes (STING) signaling primes NLRP3 transcription, its post-translational control over NLRP3 stability during lung I/R remai...

Tian Xia, Ming-Liang Wang, Dong Yang et al. · 0 citations
Jul 2026

USP20-mediated PGAM1 stabilization promotes glycolysis and confers osimertinib resistance in non-small cell lung carcinoma

This study shows that elevated USP20 expression drives osimertinib resistance and is associated with poor clinical outcomes in osimertinib-resistant NSCLC, and identifies compound 89131-02-2 as a novel and selective inhibitor that targets the USP20 C154 catalytic site.

Yunchong Meng, Xiaojun Wang, Shihao Wu et al. · 0 citations

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