Open access
Sep 2026
Hepatic PDIA5 improves hyperglycaemia and insulin resistance through stabilisation of ATF6.
The results establish PDIA5 as a critical molecular checkpoint linking hepatic lipid overload to glucose dysregulation, and highlight it as a potential therapeutic target for type 2 diabetes.
Jin-Tao Wan, Ming-Liang Zhang, Teng Ma et al.
· Diabetologia · 0 citations