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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ming Lu

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Open access Oct 2026

Apoptotic cell overload drives multinucleated giant cell formation after neoadjuvant chemotherapy in colorectal cancer: molecular mechanisms and tumor-suppressive effects

Colorectal cancer is a common digestive malignancy. Neoadjuvant chemotherapy (NAC) can downstage tumors and increase R0 resection rates. In colorectal cancer specimens with favorable pathological regression after NAC, we observed CD68 + multinucleated giant cells (MGCs) preferentially localized in apoptotic cell-...

Jia-Xin Xue, Zhi-Wei Wang, Xiao-Liang Zhang et al. · 0 citations

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