Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with a high disability rate. Its core pathogenesis involves immune dysregulation, characterized notably by the aberrant polarization of macrophages toward the pro-inflammatory M1 phenotype, along with the abnormal proliferation and invasion...
Yao Wang, Meng Lin, Qi Sun et al.· International Journal of Nan...· 0 citations
Abstract The clinical translation and long-term efficacy of PEGylation technology are increasingly jeopardized by its inherent immunogenicity, particularly the induction of anti-PEG antibodies (APAs) and the subsequent accelerated blood clearance (ABC) phenomenon. Furthermore, challenges such as frequent dosing regimen...
Ze-Fan Liu, Yu-Cheng Xiang, Gui-Lin Cheng et al.· International Journal of Nan...· 0 citations
Nanodrug delivery systems have shown great promise against tumors, inflammatory diseases and central nervous system disorders. However, several limitations still exist before further clinical application. The unsatisfactory circulation time in vivo, rapid clearance by the mononuclear phagocyte system, insufficient tiss...
Hua-Ying Pan, Juan Yang, Jia-Qi Fu et al.· Pharmaceutics· 0 citations
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