A bacillomycin D lipopeptide controls Aspergillus flavus through membrane disruption and an L-homoserine-linked redox imbalance.
Aspergillus flavus and its aflatoxins threaten global food safety, creating an urgent need for microbial biocontrol agents. Here, we isolated Bacillus velezensis 1-11-2 from soil and identified its primary antifungal metabolite as a bacillomycin D-type cyclic lipopeptide, bacillomycin D2. Bacillomycin D2 inhibited A. f...