Author

Ming-Rong Zhang

2 papers indexed here

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Open access Aug 2026

Development and Preclinical Evaluation of a Novel PET Probe for Phosphodiesterase 7B Imaging in Brain.

Phosphodiesterase 7B (PDE7B) is involved in the cAMP-PKA signaling pathway and has been implicated in neurodegenerative disorders. Accordingly, PDE7B represents a promising target for the development of therapeutics to treat such diseases. Recent efforts have led to the discovery of pyrimidinone-based compounds with hi...

T. Yamasaki, Zhi-Wei Xiao, Masayuki Fujinaga et al. · ACS Chemical Neuroscience · 0 citations

Open access Sep 2026

Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (18F) Positron Emission Tomography.

BACKGROUND Florzolotau (18F) positron emission tomography (florzolotau PET) enables high-contrast in vivo detection of four-repeat tau pathology in progressive supranuclear palsy (PSP), but whether longitudinal tau imaging reflects disease progression remains unclear. OBJECTIVES To explore longitudinal tau accumulati...

Yoshikazu Chishiki, Kenji Tagai, Y. Kataoka et al. · Movement Disorders · 0 citations