Open access
Sep 2026
A scalable, high-throughput glue perturbation screening platform for molecular glue discovery
Summary The discovery of molecular glue degraders (MGDs) is undergoing a paradigm shift from serendipitous discovery toward empirical design. However, efficiently prioritizing active leads from synthetic libraries while simultaneously confirming their E3 dependency remains a formidable challenge. In this study, we intr...
Di-Yun Huang, Ze-Yu Shuang, Lu Chen et al.
· iScience · 0 citations