Author

Ming Wang

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Open access Jul 2026

Deletion of 12/15-Lipoxygenase Preserves Retinal Thickness and Function and Selectively Restores Dysregulated miRNAs in Experimental Diabetes Mice

Diabetic retinopathy (DR) remains a leading cause of blindness, characterized by progressive neurovascular dysfunction. While the enzyme 12/15-lipoxygenase (12/15-LO) and its metabolites are upregulated in DR, their interactions with epigenetic regulators, such as miRNAs, are poorly understood. This study investigates...

Mohamed Moustafa, Youstina Guirguis, Julia Humble et al. · Diabetes · 0 citations

Jul 2026

The LncRNA CRNDE/miR-152-3p/ROCK1 axis aggravates neurological deficits and neuroinflammation in intracerebral hemorrhage.

OBJECTIVE Intracerebral hemorrhage (ICH) is a fatal cerebrovascular disease. This study explored the intrinsic relationship between ICH and lncRNA CRNDE. METHODS Injecting the lentiviral interference vector (sh-CRNDE) into the ICH mice (induced by collagenase). Subsequently, the neurological deficits were evaluated t...

Junli Xiao, Ming Wang, Haiyan Zuo et al. · Experimental Neurology · 0 citations