MAD2L1 overexpression promotes breast cancer progression and confers resistance to paclitaxel via proteasomal stabilization
Mitotic arrest deficiency protein 2-like 1 (MAD2L1) is a notable component of the spindle assembly checkpoint that ensures proper chromosome segregation during mitosis. Analysis of The Cancer Genome Atlas breast cancer datasets revealed that MAD2L1 expression was markedly upregulated in tumor tissues and was associated...