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Ming-Xia Chen

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Open access Sep 2026

Development and validation of a pharmacokinetic tool to convert random topiramate concentrations to standardized trough levels in bipolar disorder

Background Topiramate is sometimes used in patients with bipolar disorder (BD), though off-label, warranting therapeutic drug monitoring (TDM) for safety. Guidelines recommend trough-level sampling (12–16h post-dose), but random levels are common, complicating interpretation. A tool to convert random topiramate concent...

Xuan Jv, Shu-Zhen Li, Ye Liu et al. · 0 citations

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