Open access
Oct 2026
A Dual Mechanism-Based Physiologically Based Pharmacokinetic Model for Predicting Mitoxantrone and Liposomal Mitoxantrone Disposition: Preclinical Validation in Rats and Human Extrapolation with Clinical Evaluation
Purpose This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to quantitatively predict plasma and tissue concentrations of both liposomal-encapsulated and free mitoxantrone in rats and further extrapolate the model to human clinical scenarios. Methods A dual-compartment PBPK framework was co...
Yu-Xiang Xu, Shuo Li, Zhi-Xuan Yang et al.
· International Journal of Nan... · 0 citations