Atlastin 1 functions as a pro-viral factor during GCRV infection by interacting with viral NS80 and perturbing cellular redox homeostasis.
Grass carp reovirus (GCRV) causes severe hemorrhagic disease in farmed grass carp, yet how GCRV exploits host membrane remodeling machinery to support replication remains poorly defined. Here, we identified grass carp atlastin-1 (gcATL1), an endoplasmic reticulum (ER) membrane-fusion GTPase, as a pro-viral host factor...