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Author

Ming-Yuan Du

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Review Sep 2026

Recent Advances and Future Challenges of Bispecific Antibodies in Lung Cancer.

Bispecific antibodies (BsAbs) integrate two binding specificities to coordinate antitumor mechanisms that cannot be readily achieved with conventional monospecific antibodies. In lung cancer, these agents encompass four principal strategies: dual targeting of tumor-associated receptors, immune-cell redirection, simulta...

Ming-Yuan Du, Yi-Chao Han, Run-Sen Jin et al. · 0 citations
Open access Sep 2026

Tumor-intrinsic NSUN2 orchestrates immunosuppression in lung adenocarcinoma via the m5C-HDAC8-CCL5 axis

Insufficient T-cell infiltration is a major barrier to the efficacy of immune checkpoint inhibitors (ICIs) in lung adenocarcinoma (LUAD). We aimed to investigate how the tumor-intrinsic m5C methyltransferase NSUN2 shapes the immune landscape of LUAD. Nsun2 conditional knockout mice and syngeneic mice models were employ...

Wang-Yang Meng, Tong Lu, Ming-Yuan Du et al. · 0 citations

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