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Ming-Yue Li

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Open access Sep 2026

PROComb: A Practical and Robust Design With Randomization to Optimize Dose Combinations in Drug Combination Trials

The US Food and Drug Administration's Project Optimus has initiated a paradigm shift in oncology drug development from “more is better” to “less is more.” Methodological development for combination therapy trials remains limited due to their complex dose‐combination space and the need to integrate multi‐source data, in...

Ying-Jie Qiu, Ming-Yue Li · 0 citations

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