Ming-Zhao Xu

Relative suppression of pyroptosis- and necroptosis-related transcriptional programs and enrichment of ferroptosis-related signatures are associated with fatal sepsis: multi-cohort bulk and single-cell transcriptomic evidence

Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection and remains a major cause of mortality in critically ill patients. Multiple forms of programmed cell death (PCD) may contribute to immune dysregulation and organ injury, but their transcriptional patterns across disease severi...