Spatial multi-omics analysis reveals vimentinhigh macrophages–endothelial cells niche shapes CAFs heterogeneity in colorectal cancer metastasis
The spatial architecture of the tumor microenvironment (TME) is pivotal in the progression of colorectal cancer (CRC) liver metastasis. By applying high-plex spatial multi-omic mapping and neighborhood analysis to a discovery cohort of colorectal cancer primary tumor (PT) and paired liver metastases (LM), we identified...