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Author

Minji Byun

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Open access Sep 2026

Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration

Findings link clonal hematopoiesis-associated epigenetic alterations to selective transcriptional reprogramming and altered function of differentiated myeloid cells to isogenic human embryonic stem cell-derived macrophages.

Yuri Lee, Philip K. Farahat, J. Nguyen et al. · 0 citations
Open access Aug 2026

Systems genetics approaches model the heritable architecture of polyendocrine metabolic ovarian syndrome.

It is shown that increased ovarian area contributes to both PMOS susceptibility and ovarian cancer progression, while specific ovary-heart signaling circuits modulate cardiac function with aging, and SF3B1-mediated splicing is uncovered as a link between ovary function and systemic metabolism.

Christy M. Nguyen, L. Velez, Youngseo Cheon et al. · 0 citations

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