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Author

Minji Jeon

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Open access Sep 2026

DEG2MOL: Conditional Latent Flow Matching for Transcriptome-Guided de novo Drug Design

Transcriptomic profiles capture cellular responses to perturbations, offering a principled foundation for biologically grounded de novo drug design. However, existing transcriptome-guided generative approaches remain limited in biological specificity, transcriptomic coverage, and evaluation across diverse perturbatio...

Songhyeon Kim, Wootaek Lim, Hawon Lee et al. · 0 citations
Review Open access Jul 2026

DR.DEGMON: self-explainable deep neural network for drug-induced cell viability prediction incorporating differentially expressed genes and gene ontology

The integration of GO and LRP enabled the model to suggest the underlying biological processes involved in drug responses, making it a valuable tool for predicting outcomes and discovering new biomedical knowledge in cancer pharmacogenomics.

Wootaek Lim, Jitae Kim, Songhyeon Kim et al. · 0 citations

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