Improved oral bioavailability of dihydromyricetin using β-cyclodextrin-grafted chitosan/tocopheryl polyethylene glycol succinate nano-delivery system: preparation, characterization, in-vitro evaluation and pharmacokinetics.
The low oral bioavailability of Dihydromyricetin(DMY), resulting from its instability and poor absorption in the gastrointestinal tract, limits its pharmaceutical applications. In order to enhance the oral bioavailability of DMY, a DMY@CD-CS/TPGS nano-delivery system was successfully prepared using β-cyclodextrin graft...