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Author

Minori Aoki

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Open access Jul 2026

Pharmacological Disruption of Glioblastoma Extracellular Vesicle-Myeloid Cell Interactions Mitigates Tumor-Induced Immunosuppression 2259453

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by profound immunosuppression that hinders the effect of immunotherapies. Myeloid-derived suppressor cells (MDSCs), which dampen anti-tumor immune responses, are major contributors to this immunosuppression. GBM-deri...

Minori Aoki, Mohammad Asad, Carolyn Baker et al. · 0 citations
Jul 2026

Tumor extracellular vesicles induce immunosuppressive myeloid cells via TIGIT/CD155 axis, dampening NLRP3-driven inflammatory response in glioblastoma 2257553

Glioblastoma (GBM), the most aggressive primary brain tumor in adults, is marked by profound immune suppression. Tumor-derived extracellular vesicles (TEVs) are increasingly recognized as key mediators of this immunosuppressive environment. In this study, we examined the tumor-immune microenvironment using...

Mohammad Asad, Julio F. Inocencio, Stefan Mitrasinovic et al. · 0 citations

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