Review
Sep 2026
From beta-cell stress to tertiary lymphoid structure formation: a stage-dependent framework for interpreting type 1 diabetes progression.
A stage-dependent conceptual framework linking beta-cell stress, innate immune activation, and TLS-mediated stabilization of chronic inflammation is presented, providing a rationale for the limited durability of current immune-targeted therapies and identifying experimentally testable hypotheses.
T. Alramadneh, Aziz Kubaev, Shakir Mahmood Saeed et al.
· Diabetes Research and Clinic... · 0 citations