Abstract B089: Ferroptosis-associated iron-high pancreatic cancer cells downregulate interferon-induced MHC class II despite intact interferon signaling, limiting tumor antigen presentation to CD4+ T cells
Ferroptosis is canonically immunogenic, yet its induction in pancreatic ductal adenocarcinoma (PDAC) fails to prime anti-tumor immunity and accelerates tumor growth, limiting the development of ferroptosis-based immunotherapy. Studies have induced ferroptosis experimentally, but no transcriptional score reliably...