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Minseon Gu

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Sep 2026

Abstract B089: Ferroptosis-associated iron-high pancreatic cancer cells downregulate interferon-induced MHC class II despite intact interferon signaling, limiting tumor antigen presentation to CD4+ T cells

Ferroptosis is canonically immunogenic, yet its induction in pancreatic ductal adenocarcinoma (PDAC) fails to prime anti-tumor immunity and accelerates tumor growth, limiting the development of ferroptosis-based immunotherapy. Studies have induced ferroptosis experimentally, but no transcriptional score reliably...

Minseon Gu, J. Jo, H. Lee · 0 citations

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