Open access
Aug 2026
Upregulation of ITM2A by p53 activation modulates p53 function through physical interaction.
It is found that p53 upregulates ITM2A expression, while ITM2A in turn inhibits p53 function, suggesting a negative feedback loop and suggesting ITM2A as a potential prognostic marker and therapeutic target for cancers with dysregulated p53 signaling.
Sim Namkoong, Min-Su Jang, Jeong‐In Lee et al.
· Cell Cycle · 0 citations