Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response
This work integrates transcriptomics with whole-cell and purified mitochondrial proteomics to profile lipopolysaccharide (LPS)/interferon-γ (IFN-γ)– and interleukin-4 (IL-4)/IL-13–stimulated macrophages and identifies mtDNA expression, intramitochondrial translation, and mitochondrial membrane potential as critical, dr...