Open access
Sep 2026
The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and behavior of their reconstructed ancestors
Abstract Homing endonucleases (HEs) are selfish genetic elements that drive the mobilization of their own coding sequences, often in concert with surrounding introns. Homing endonuclease genes (HEGs) usually display life cycles in which they accumulate inactivating mutations after invading a host genomic target site, l...
Janet M. Young, A. Lambert, Janet M. Young et al.
· Nucleic Acids Research · 0 citations