Mitsuki Shibagaki

Calmodulin-tagging prevents aggregation and facilitates the proteolytic release of the recombinant human cathelicidin LL-37 by accommodating its hydrophobic regions.

The human cathelicidin LL-37 is a widely studied 37-residue antimicrobial peptide with diverse biological functions. However, its strong aggregation propensity hinders the efficient recombinant production of this peptide. Previously reported expression strategies often face limitations such as low solubility, inefficie...