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Oct 2026

Histone lactylation-upregulated CEBPB transcriptionally activates CXCL12 and p21 to modulate vascular smooth muscle cell senescence and macrophage polarization.

BACKGROUND Abdominal aortic aneurysm (AAA) represents a widespread vascular disorder associated with high significant mortality rates, and the phenotypic transformation of vascular smooth muscle cells (VSMCs) acts as a crucial pathological characteristic during the advancement of this condition. Recent studies suggest...

Yong-Xin Han, Jia-Cheng Wang, Ru-Chen Li et al. · 0 citations
Review Open access Jul 2026

Unveiling the new horizons of atherosclerosis: the crossroads of inflammation, pyroptosis, and immunity

This review provides a systematic overview of immune microenvironment remodeling and the mechanisms of pyroptosis during the onset and progression of atherosclerosis, and summarizes emerging therapeutic strategies targeting immune regulation and pyroptosis pathways, including NLRP3 inhibitors, cytokine- targeting agent...

Yi-Fan Wang, G. Dong, Yun-Shan Wang et al. · 0 citations

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