Open access
Jul 2026
Peptide Nucleic Acid Probes for Pretargeted Affibody-Mediated Delivery of Cytotoxic Payloads to HER2-Positive Carcinoma
These findings highlight how rational design can optimize in vivo pharmacokinetics while preserving binding properties essential for effective pretargeting, providing a foundation for developing novel targeted cytotoxic delivery systems with potentially improved therapeutic indexes.
Jacob Clinton, K. Westerlund, Astrid Haraldsson et al.
· Bioconjugate chemistry · 0 citations