Author

Mohamed M. Salama

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Open access Oct 2026

Alpha-Lipoic Acid and Saxagliptin Attenuate Ferroptosis-Related Ovarian Injury and Modulate FGF21/NOX4–NRF2/HO-1 Signaling in Letrozole-Induced Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by ovarian dysfunction, hormonal imbalance, and emerging ferroptosis-related abnormalities. This study investigated the effects of alpha-lipoic acid (ALA), saxagliptin (Saxa), and their combination in a letrozole-induced PCOS model...

Eman H. Yousef, Mona H. Zohny, Ebtsam S. Abdel-lah et al. · International Journal of Mol... · 0 citations

Review Sep 2026

Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP.

Berberine, a naturally occurring isoquinoline alkaloid found in several medicinal plants such as Berberis spp. and Coptis chinensis has long been used in traditional medicine. Recent evidence positions berberine as a pleiotropic modulator of multiple interconnected hallmarks of aging, making it a promising candidate fo...

S. M. Alanazi, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al. · Fitoterapia · 0 citations

Review Sep 2026

Targeting the α7-nicotinic acetylcholine receptor in multiple sclerosis: Implications for immunomodulation and neuroprotection.

By integrating immunomodulatory and neuroprotective actions, α7-nAChR targeting represents a mechanistically compelling strategy for comprehensive disease modification in MS, although clinical translation remains contingent upon overcoming significant pharmacological and biomarker-related challenges.

A. Al-Dhahi, Hayder M. Al-kuraishy, Ahmed A. Mohamed et al. · Life Science · 0 citations