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Author

Mohamed S. Donia

2 papers indexed here

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Open access Sep 2026

Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation.

Elucidating the biological origins and biosynthetic pathways of marine natural products remains a major challenge, particularly for compounds derived from microbial consortia. Here, we identify the marine cyanobacterial genus Dapis as the source of the potent anticancer natural product dolastatin 15 using genome-resolv...

Man-Yun Chen, Jie Liu, Hsin-Ying Tsai et al. · 0 citations
Open access Jul 2026

Digestion-resistant proteins support the healthy metabolite profiles associated with plant-based diets.

Plant-based diets are associated with both positive health outcomes and a diverse gut microbiome. Such diets alter the microbiome's metabolic outputs, including increasing phenylalanine-derived phenols associated with beneficial health outcomes (hippuric acid and 3-phenylpropionate), while decreasing tyrosine-derived p...

Jenna E. AbuSalim, MR MacArthur, Meera Gupta et al. · 0 citations

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