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Author

Mohammad Esfini Farahani

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Review Sep 2026

BRN2 in Lineage Plasticity: A Prostate Cancer-Focused Perspective.

This review examines how BRN2 connects developmental neurogenesis to therapy-induced tumor reprogramming and integrates insights from neurodevelopment and direct lineage reprogramming to describe how BRN2 maintains stem-like and neuroendocrine transcriptional states.

Fatemeh Seilani, Jia Peng, Meng Wu et al. · 0 citations
Open access Jul 2026

Abbapolin inhibitors of the PLK1 PBD as Prostate Cancer Therapeutics, in vivo activity and synergy with androgen therapy

These studies establish selective inhibition of the PLK1 Polo-box domain as a viable therapeutic strategy, provide in vivo proof-of-concept for the REPLACE approach, and identify abbapolins as promising leads for advanced prostate cancer.

George Merhej, Gurusankar Ramamoorthy, Danda Chapagai et al. · 0 citations

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