Author

Mohammad Mehdi Akbarin

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Review Open access Aug 2026

Host genetic determinants of HTLV-1 infection outcomes

Human T-cell lymphotropic virus type 1 (HTLV-1) is a persistent human retrovirus associated with severe outcomes, most notably adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite lifelong infection, only a minority of carriers develop clinical disease,...

Mohammad Mehdi Akbarin, Zahra Farjami, H. R. Álvarez · Immunologic research · 0 citations

Open access Sep 2026

Integrative pooled transcriptomic analysis reveals shared and distinct molecular signatures in adult T-cell leukemia/lymphoma and peripheral T-cell lymphoma

Adult T-cell leukemia/lymphoma (ATLL) and peripheral T-cell lymphomas (PTCLs) are aggressive neoplasms of mature T cells with poor prognosis and limited therapies. ATLL originates from HTLV-1 infection, while PTCL comprises heterogeneous subtypes without a defined etiologic factor. Comparative molecular profiling of th...

Mohammad Mehdi Akbarin, Zahra Farjami, H. R. Álvarez · Functional & Integrative Gen... · 0 citations