Central lactate uptake during exercise contributes to hypothalamic fibroblast growth factor 21 induction and systemic fat mobilization.
Fibroblast growth factor 21 (FGF21) regulates lipid metabolism, and lactate may act centrally to modulate energy homeostasis. This study examined whether central FGF21 contributes to exercise-induced fat oxidation and whether central lactate regulates its induction and sympathetic-driven lipolysis. Male Wistar rats rec...