Author

Mohan Chen

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Aug 2026

A lysosome-targeted and polarity-responsive photosensitizer for tumor specific imaging and photodynamic therapy.

A lysosome-targeted photosensitizer HBT-CUR with D-π-A feature based on 2-(2'-hydroxyphenyl) benzothiazole (HBT) and difluoroborate moieties for tumor image-guided PDT is designed and synthesized, offering a new strategy for the rational design and development of tumor PDT systems.

Mohan Chen, Zhennan Zhang, Jiahui Zhuang et al. · Bioorganic chemistry (Print) · 0 citations

Aug 2026

Caged Glycan-Antibody Conjugates for Tumor-Selective Activation of Lysosome-Targeting Chimeras.

A chemically activatable LYTAC platform that leverages tumor microenvironment-specific cues to achieve precise and safe protein degradation in vivo is reported, significantly enhancing the safety and therapeutic window of lysosome-targeted degradation strategies in cancer therapy.

Mohan Chen, Yi-Cun Li, Xue-Ting Wei et al. · Journal of Medicinal Chemist... · 0 citations