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Author

Mohit Kumar

2 papers indexed here

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Review Sep 2026

Advances in Novel Drug Delivery Systems for Targeting the Brain: Overcoming Barriers and Enhancing Therapeutic Efficacy.

The blood-brain barrier (BBB) is critical in CNS pharmacotherapy; it blocks the entry of 98 per cent of small-molecule compounds and almost all macromolecules into the brain parenchyma via tight junction complexes, efflux transporter action, and enzymatic breakdown. This review focuses on the mechanistic basis of BBB r...

Manish R. Bhise, K. Thejomoorthy, Mohit Kumar et al. · 0 citations
Open access Jul 2026

DESIGN, SYNTHESIS, AND IN VITRO SCREENING OF MACROCYCLIC UREA-BASED HETEROCYCLIC SYSTEMS WITH UNUSUAL RING CONSTRAINTS

Macrocycles are highly privileged scaffolds in contemporary drug discovery, yet their inherent structural flexibility often imposes severe entropic penalties upon target binding. We report the rational design, synthesis, and comprehensive biological evaluation of a novel class of macrocyclic ureas that incorporate an u...

P. M.R., Palati Divya Jyothi, G. Hemalatha et al. · 0 citations

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